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1.
Ligand-Based Design of Selective Peptidomimetic uPA and TMPRSS2 Inhibitors with Arg Bioisosteres.
Int J Mol Sci
; 25(3)2024 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-38338655
2.
Next Generation of Fluorometric Protease Assays: 7-Nitrobenz-2-oxa-1,3-diazol-4-yl-amides (NBD-Amides) as Class-Spanning Protease Substrates.
Chemistry
; 29(50): e202301855, 2023 Sep 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37313627
3.
Influence of amino acid size at the P3 position of N-Cbz-tripeptide Michael acceptors targeting falcipain-2 and rhodesain for the treatment of malaria and human african trypanosomiasis.
Bioorg Chem
; 137: 106587, 2023 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37163812
4.
A structure-based virtual high-throughput screening, molecular docking, molecular dynamics and MM/PBSA study identified novel putative drug-like dual inhibitors of trypanosomal cruzain and rhodesain cysteine proteases.
Mol Divers
; 2023 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-36617352
5.
Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors-A Comprehensive Reactivity and Selectivity Study.
Int J Mol Sci
; 24(8)2023 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37108388
6.
Drug Combination Studies of the Dipeptide Nitrile CD24 with Curcumin: A New Strategy to Synergistically Inhibit Rhodesain of Trypanosoma brucei rhodesiense.
Int J Mol Sci
; 23(22)2022 Nov 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-36430948
7.
Lead Discovery of SARS-CoV-2 Main Protease Inhibitors through Covalent Docking-Based Virtual Screening.
J Chem Inf Model
; 61(4): 2062-2073, 2021 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-33784094
8.
Dual Strategy to Design New Agents Targeting Schistosoma mansoni: Advancing Phenotypic and SmCB1 Inhibitors for Improved Efficacy.
ACS Infect Dis
; 10(5): 1664-1678, 2024 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-38686397
9.
Peptidyl nitroalkene inhibitors of main protease rationalized by computational and crystallographic investigations as antivirals against SARS-CoV-2.
Commun Chem
; 7(1): 15, 2024 Jan 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-38238420
10.
A low-cost 3D-printable differential scanning fluorometer for protein and RNA melting experiments.
HardwareX
; 11: e00256, 2022 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-35509940
11.
Development of Urea-Bond-Containing Michael Acceptors as Antitrypanosomal Agents Targeting Rhodesain.
ACS Med Chem Lett
; 13(7): 1083-1090, 2022 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35859868
12.
Warhead Reactivity Limits the Speed of Inhibition of the Cysteine Protease Rhodesain.
ACS Chem Biol
; 16(4): 661-670, 2021 04 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-33719398
13.
Structure-Activity Relationships of Benzamides and Isoindolines Designed as SARS-CoV Protease Inhibitors Effective against SARS-CoV-2.
ChemMedChem
; 16(2): 340-354, 2021 01 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-32930481
14.
Fluorovinylsulfones and -Sulfonates as Potent Covalent Reversible Inhibitors of the Trypanosomal Cysteine Protease Rhodesain: Structure-Activity Relationship, Inhibition Mechanism, Metabolism, and In Vivo Studies.
J Med Chem
; 64(16): 12322-12358, 2021 08 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-34378914
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